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KMID : 1098420100180030143
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Korean Journal of Medicinal Crop Science
2010 Volume.18 No. 3 p.143 ~ p.150
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Enhancement of Anticancer Activities of Ephedra sinica Stapf Extracts by Nano-encapsulation
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Jeong Hyang-Suk
Kim Seoung-Seop
Oh Sung-Ho
Jeong Myoung-Hoon
Choi Woon-Yong
Seo Yong-Chang
Na Chun-Soo
Kwak Hyeong-Geun
Lee Hyeon-Yong
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Abstract
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This study showed the increase of antitumor activities of water soluble E. sinica extract by nano-encapsulation process with lecithin. Five groups of lecithin only group (LO), lecithin nano-encapsulated E. sinica group (LE), E. sinica only group (EO), one negative control group (NCO) and positive control group (PCO) were set for several anticancer experiment and fed into Sarcoma-180 injected mice. The cytotoxicity of LE on the human normal kidney cell (HEK293) showed 14.8% lower than 19.2% of EO and 18.4% of LO. Growth of human liver carcinoma cell and human stomach carcinoma cell as representative of digestive system in vitro was inhibited up to about 85.1% and 87.3%, in adding 1.0 ㎎/㎖ of LE, which values 15% higher than that from conventional EO. The survival rates of each mice group were 40%, 63%, 48%, 33% and 100%, respectively after 40 days of injecting Sarcoma-180. The increment of their body weights of the extract feeding groups was suppressed down to 10~15%, compared to the negative control. The nano-particles also reduced the hypertrophy of the internal organs such as spleen and liver down to 15~20%, compared to those as the other groups. Among them, LE effectively reduced the size of tumor form to 20%. From these results, in vitro and in vivo antitumor activities of E. sinica could be enhanced by using nano-encapsulation process with lecithin because of better permeation into the cancer cells by confocal observations.
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KEYWORD
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Nano-encapsulation, Ephedra sinica Stapf, Antitumor Activities, Lecithin
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